Repost from @drgoodfood
- Ay-can-THOE-sis NIE-gri-cans. ACANTHOSIS NIGRICANS (AN) is a cutaneous sign of an underlying condition or disease that causes one or more areas to darken and thicken, often with a velvety texture.
CAUSES: Causal relationship w/ insulin resistance.
* Pre-diabetic or diabetic
* Hormonal conditions
Anyone can develop this skin condition, but most at risk are obese or overweight individuals, Native American, African, Caribbean, or Hispanic descent, or from a family with a history of AN.
🔸 Obesity-associated, “pseudo-acanthosis
🔸 Benign genetic
🔸 Malignant 🔸 Mixed-type
🔹 Grey-brown/black discoloration
🔹 Dryness, roughness, itching
🔹 Associated skin tags
The most common areas of the body include armpits, posterior neck, body folds, elbows, knees, face, and knuckles. It affects the lips, mouth, eyelids, and palms of the hands less often. Lesions involving the mucosa, palms, and soles tend to be more extensive and more severe in malignant AN. TRIPE PALMS is associated with malignancy in 90%, with gastric cancer being the most frequent.
Treatment is difficult but the primary goal is to correct the underlying disease process, which includes diet and/or medication, exercise, cessation of offending drug(s), or treatment of an underlying tumor.
♦️ Topical retinoids
♦️ Ammonium lactate
♦️ Calcipotriol (derivative of Vit D)
♦️ Salicylic acid
♦️ Triple combination cream
♦️ Oral agents (ie. metformin, oral retinoids)
My patient achieved clearance in 12 weeks with a combo of #salicylicacid
, ammonium lactate, triple combination cream, #mandelicacid
, and strict sunscreen use, with f/u by her PCP due to an underlying history of DM 👩🏾⚕️
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